The main objectives of this study were to access the utilization awareness and effectiveness of search engines and knowledge portals among the scientists and research scholars of Central Drug Research Institute, Lucknow. In order to achieve the specific objectives stated, a researchers, designed questionnaire was distributed on 250 two hundred fifty, respondents (two hundred fifteen respondents from Central Drug Research Institute, Lucknow). The results which were specified to weighted mean and percentages showed that the respondents excellent and very good exposed awareness the ease of navigation/use information available on search engines and knowledge portals with the weighted mean methods. The results on the level Completeness/Adequacy and Quantity of Information Available on Search Engines and Knowledge Portals respondent felt very good. The results of barriers encountered exposed that the most respondents agreed they encountered “lack of reliable information” ranked first barrier, which was followed by “access difficulties (slow c connectivity)”, “lack of knowledge about availability, and “fear of copyright and infringement or plagiarism” giving the rank distinctly for barriers. The option “lack of IT infrastructure facilities (hardware and software inadequacies)” was categorized at lowest fifth situation. Based on the findings, it was recommended that since the search engines and knowledge portals is being very much utilized and effective the scientists and researchers of CDRI, Lucknow required to be exposed advance merchant techniques through information literacy programmes or other awareness and internet, IT facilities should be made available to the CDRI library.