This study investigates the connection between creative work practices and psychological empowerment among pharmaceutical industry workers. A systematic questionnaire was used to gather data from 221 employees from various pharmaceutical companies who took part in the study. The impact of psychological empowerment dimensions – meaning, competence, self-determination, and impact – on individual innovation was evaluated using quantitative analysis, including correlation and regression techniques. The results show a strong favourable correlation between creative work practices and psychological empowerment. Workers that feel more empowered are more inclined to come up with ideas, try new things, and put innovative solutions into practice. These findings have significant practical ramifications for the pharmaceutical sector, where growth and competitiveness depend heavily on innovation. By increasing employee autonomy, offering chances for ongoing learning, and fostering a strong sense of purpose at work, HR managers and organisational leaders can encourage innovative behaviour. Organisations can increase employee engagement and maintain long-term adaptability in a changing business environment by bolstering empowerment strategies.