This study focuses on the professional commitment of the nursing professionals with reference to the four zones in India. The study uses a multi-stage sampling method in which 376 nursing staff from 32 hospitals responded. The nursing staff revealed a higher mean for all the variables of professional commitment. However, there is the significant difference in the mean professional attitude, professional involvement and total professional commitment level among the four zones of India. Factors like career opportunities, pay packages, foreign jobs, patient counseling, role of a trade-union, socioeconomic conditions of the regions and the likes may affect the professional commitment of the nursing staff. The HR managers should understand the diversity of the four zones and develop HR policies accordingly.