This is a study of the relationship between organizational commitment, employee empowerment and career satisfaction of female work force.Women employees working in India have been approached for investigation of variables in this study. The results of the analysis state that organizational commitment and career satisfaction have a positive relationship. Employee empowerment has a positive moderating impact on the relationship of organizational commitment with career satisfaction of female gender. The outcome of the study establishes the importance of empowering women employees in the organization for ensuring higher career satisfaction. The framework brings insights for managers and organizations to establish policies and practices which facilitate women empowerment. This would result in the long-term growth of the organization.